Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's disease.

doi:10.1016/j.neuropharm.2014.02.010

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Article

Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's disease.

Neuropharmacology - 1 Jun 2014

Do Tuan Minh, Alata Wael, Dodacki Agnès, Traversy Marie-Thérèse, Chacun Hélène, Pradier Laurent, Scherrmann Jean-Michel, Farinotti Robert, Calon Frédéric, Bourasset Fanchon

Abstract excerpt

We evaluated the integrity and function of the blood-brain barrier in 3xTg-AD mice aged 3-18 months and in APP/PS1 mice aged 8-months to determine the impacts of changes in amyloid and tau proteins on the brain vascular changes. The vascular volume (Vvasc) was sub-normal in 3xTg-AD mice aged from 6 to 18 months, but not in the APP/PS1 mice. The uptakes of [(3)H]-diazepam by the brains of 3xTg-AD, APP/PS1 and...

Topics

Age Factors
Alzheimer Disease
Amyloid beta-Protein Precursor
Animals
Blood-Brain Barrier
Brain
Cerebrovascular Circulation
Diazepam
Disease Models, Animal
Functional Laterality

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glucose

Glucose Transporter Type 1

Humans

Mice

Mice, Transgenic

Microvessels

Mutation

Presenilin-1

Source

Open in PubMed

Identifiers

PMID: 24631967
DOI: 10.1016/j.neuropharm.2014.02.010

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24631967-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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