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Article

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy.

Acta neuropathologica - 1 Apr 2011

Hawkes Cheryl A, Härtig Wolfgang, Kacza Johannes, Schliebs Reinhard, Weller Roy O, Nicoll James A, Carare Roxana O

Abstract excerpt

The deposition of amyloid-β (Aβ) peptides in the walls of leptomeningeal and cortical blood vessels as cerebral amyloid angiopathy (CAA) is present in normal ageing and the majority of Alzheimer's disease (AD) brains. The failure of clearance mechanisms to eliminate Aβ from the brain contributes to the development of sporadic CAA and AD. Here, we investigated the effects of CAA and ageing on the pattern of...

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PMID: 21259015
DOI: 10.1007/s00401-011-0801-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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