Article
Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations.
The American journal of pathology - 1 Jan 2010
Gama Sosa Miguel A, Gasperi Rita De, Rocher Anne B, Wang Athena Ching-Jung, Janssen William G M, Flores Tony, Perez Gissel M, Schmeidler James, Dickstein Dara L, Hof Patrick R, Elder Gregory A
Abstract excerpt
Mutations in the presenilin 1 (PS1) gene are the most commonly recognized cause of familial Alzheimer's disease (FAD). Besides senile plaques, neurofibrillary tangles, and neuronal loss, Alzheimer's disease (AD) is also accompanied by vascular pathology. Here we describe an age-related vascular pathology in two lines of PS1 FAD-mutant transgenic mice that mimics many features of the vascular pathology seen in AD....
Topics
- Aging
- Alzheimer Disease
- Animals
- Atrophy
- Basement Membrane
- Blood Vessels
- Brain
- Chromosomes, Artificial, P1 Bacteriophage
- Dendrites
- Extracellular Matrix Proteins