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Article

Axons degenerate in the absence of mitochondria in C. elegans.

Current biology : CB - 31 Mar 2014

Rawson Randi L, Yam Lung, Weimer Robby M, Bend Eric G, Hartwieg Erika, Horvitz H Robert, Clark Scott G, Jorgensen Erik M

Abstract excerpt

Many neurodegenerative disorders are associated with mitochondrial defects [1-3]. Mitochondria can play an active role in degeneration by releasing reactive oxygen species and apoptotic factors [4-7]. Alternatively, mitochondria can protect axons from stress and insults, for example by buffering calcium [8]. Recent studies manipulating mitochondria lend support to both of these models [9-13]. Here, we identify a...

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Identifiers

PMID: 24631238
DOI: 10.1016/j.cub.2014.02.025
PMCID: PMC4018749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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