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Article

A histidine-rich linker region in peptidylglycine α-amidating monooxygenase has the properties of a pH sensor.

The Journal of biological chemistry - 2 May 2014

Vishwanatha Kurutihalli, Bäck Nils, Mains Richard E, Eipper Betty A

Abstract excerpt

Decreasing luminal pH is thought to play a role in the entry of newly synthesized and endocytosed membrane proteins into secretory granules. The two catalytic domains of peptidylglycine α-amidating monooxygenase (PAM), a type I integral membrane protein, catalyze the sequential reactions that convert peptidyl-Gly substrates into amidated products. We explored the hypothesis that a conserved His-rich cluster...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24627494
DOI: 10.1074/jbc.M113.545947
PMCID: PMC4007436

Genes

PAM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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