Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Location of the pteroylpolyglutamate-binding site on rabbit cytosolic serine hydroxymethyltransferase.

The Journal of biological chemistry - 24 Jan 2003

Fu Tzu-Fun, Scarsdale J Neel, Kazanina Galina, Schirch Verne, Wright H Tonie

Abstract excerpt

Serine hydroxymethyltransferase (SHMT; EC 2.1.2.1) catalyzes the reversible interconversion of serine and glycine with transfer of the serine side chain one-carbon group to tetrahydropteroylglutamate (H(4)PteGlu), and also the conversion of 5,10-methenyl-H(4)PteGlu to 5-formyl-H(4)PteGlu. In the cell, H(4)PteGlu carries a poly-gamma-glutamyl tail of at least 3 glutamyl residues that is required for physiological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cations
Share to Cytosol
Share to Glutamic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamine

Share to Glycine Hydroxymethyltransferase

Share to Ligands

Share to Lysine

Share to Rabbits

Source

Identifiers

PMID: 12438316
DOI: 10.1074/jbc.M210649200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Location of the pteroylpolyglutamate-binding site on rabbit cytosolic serine hydroxymethyltransferase.PMID 12438316Read ↗

Structure-based mechanism for early PLP-mediated steps of rabbit cytosolic serine hydroxymethyltransferase reaction.Semantic proximity Read ↗

The role of a critical sulfhydryl group in the mechanism of serine hydroxymethyltransferase.Semantic proximity Read ↗

A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase.Semantic proximity Read ↗

Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish γ-glutamyl hydrolase.Semantic proximity Read ↗

Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia.Semantic proximity Read ↗

Disruption of distal interactions of Arg 262 and of substrate binding to Ser 52 affect catalysis of sheep liver cytosolic serine hydroxymethyltransferase.Semantic proximity Read ↗

Screening and In Vitro Testing of Antifolate Inhibitors of Human Cytosolic Serine HydroxymethyltransferaseSemantic proximity Read ↗

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.Semantic proximity Read ↗

Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity.Semantic proximity Read ↗

Properties of human and rabbit cytosolic serine hydroxymethyltransferase are changed by single nucleotide polymorphic mutations.Semantic proximity Read ↗

The structure of serine hydroxymethyltransferase as modeled by homology and validated by site-directed mutagenesis.Semantic proximity Read ↗

Structural and biochemical characterization of the folyl‐poly‐γ‐<scp>l</scp>‐glutamate hydrolyzing activity of human glutamate carboxypeptidase <scp>II</scp>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.