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Article

A Conserved Histidine in Insulin Is Required for the Foldability of Human Proinsulin

26 May 2006

Abstract excerpt

The insulins of eutherian mammals contain histidines at positions B5 and B10. The role of His(B10) is well defined: although not required in the mature hormone for receptor binding, in the islet beta cell this side chain functions in targeting proinsulin to glucose-regulated secretory granules and provides axial zincbinding sites in storage hexamers. In contrast, the role of His(B5) is less well understood. Here,...

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PMID: 16728398
DOI: 10.1074/jbc.m602617200

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