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Article

The prosequence of human lactase-phlorizin hydrolase modulates the folding of the mature enzyme.

The Journal of biological chemistry - 8 Mar 2002

Jacob Ralf, Peters Karen, Naim Hassan Y

Abstract excerpt

The efficient transport of proteins along the secretory pathway requires that the polypeptide adopts a stably folded conformation to egress the endoplasmic reticulum (ER). The transport-competent precursor of the brush border enzyme LPH, pro-LPH, undergoes an intracellular cleavage process in the trans-Golgi network between Arg(734) and Leu(735) to yield LPH beta(initial). The role of the prodomain comprising the...

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PMID: 11751874
DOI: 10.1074/jbc.M111500200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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