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Article

Autophagy-related IRGM polymorphism is associated with mortality of patients with severe sepsis.

PloS one - 1 Jan 2014

Kimura Tomonori, Watanabe Eizo, Sakamoto Teruo, Takasu Osamu, Ikeda Toshiaki, Ikeda Kazumi, Kotani Joji, Kitamura Nobuya, Sadahiro Tomohito, Tateishi Yoshihisa, Shinozaki Koichiro, Oda Shigeto

Abstract excerpt

OBJECTIVE: Autophagy is the regulated catabolic process for recycling damaged or unnecessary organelles, which plays crucial roles in cell survival during nutrient deficiency, and innate immune defense against pathogenic microorganisms. Autophagy has been also reported to be involved in various conditions including inflammatory diseases. IRGM (human immunity-related GTPase) has an important function in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24626347
DOI: 10.1371/journal.pone.0091522
PMCID: PMC3953488

Genes

IRGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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