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Article

Association between genetic polymorphisms in the autophagy-related 5 gene promoter and the risk of sepsis.

Scientific reports - 24 Aug 2017

Shao Yiming, Chen Feng, Chen Yuhua, Zhang Wenying, Lin Yao, Cai Yujie, Yin Zihan, Tao Shoubao, Liao Qinghui, Zhao Jianghao, Mai Hui, He Yanfang, He Junbing, Cui Lili

Abstract excerpt

Previous studies demonstrated significant roles of autophagy in the pathogenesis of sepsis, but few studies focused on the effect of autophagy-related SNPs on sepsis susceptibility. In this present study, five polymorphisms of ATG5/ATG16L1 were investigated for the possible risk on sepsis in a Chinese Han population. Our results showed that ATG5 expression levels decreased with the severity of sepsis, and...

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Identifiers

PMID: 28839236
DOI: 10.1038/s41598-017-09978-5
PMCID: PMC5570943

Genes

ATG5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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