The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms.

doi:10.1073/pnas.0506643103

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Article

The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jan 2006

Cavaillès Pierre, Sergent Véronique, Bisanz Cordelia, Papapietro Olivier, Colacios Céline, Mas Magali, Subra Jean-François, Lagrange Dominique, Calise Maryline, Appolinaire Sylvie, Faraut Thomas, Druet Philippe, Saoudi Abdelhadi, Bessieres Marie-Hélène, Pipy Bernard, Cesbron-Delauw Marie-France, Fournié Gilbert J

Abstract excerpt

Toxoplasmosis is a healthcare problem in pregnant women and immunocompromised patients. Like humans, rats usually develop a subclinical chronic infection. LEW rats exhibit total resistance to Toxoplasma gondii infection, which is expressed in a dominant mode. A genome-wide search carried out in a cohort of F(2) progeny of susceptible BN and resistant LEW rats led to identify on chromosome 10 a major locus of...

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PMID: 16407112
DOI: 10.1073/pnas.0506643103
PMCID: PMC1334643

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