Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex

4 Jan 2013

Abstract excerpt

An exciting recent approach to targeting transcription factors in cancer is to block formation of oncogenic complexes. We investigated whether interfering with the interaction of the transcription factor SALL4, which is critical for leukemic cell survival, and its epigenetic partner complex represents a novel therapeutic approach. The mechanism of SALL4 in promoting leukemogenesis is at least in part mediated by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Cancer-related gene regulation
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23287862
DOI: 10.1182/blood-2012-04-424275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complexPMID 23287862Read ↗

The Role of Stem Cell Factor SALL4 in LeukemogenesisSemantic proximity Read ↗

The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesisSemantic proximity Read ↗

SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic RelevanceSemantic proximity Read ↗

SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic miceSemantic proximity Read ↗

Dissecting the role of SALL4, a newly identified stem cell factor, in chronic myelogenous leukemiaSemantic proximity Read ↗

SALL4 is a key transcription regulator in normal human hematopoiesisSemantic proximity Read ↗

SALL4B not targeted by IMiD is important for SALL4-mediated tumorigenesisSemantic proximity Read ↗

The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemiaSemantic proximity Read ↗

Identification of the nuclear localization signal of SALL4B, a stem cell transcription factor.Semantic proximity Read ↗

The SPS affair: a complex tale of illicit proliferation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.