Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biosynthesis of Mupirocin by <i>Pseudomonas fluorescens</i> NCIMB 10586 Involves Parallel Pathways

13 Mar 2014

Abstract excerpt

Mupirocin, a clinically important antibiotic produced via a trans-AT Type I polyketide synthase (PKS) in Pseudomonas fluorescens, consists of a mixture of mainly pseudomonic acids A, B, and C. Detailed metabolic profiling of mutant strains produced by systematic inactivation of PKS and tailoring genes, along with re-feeding of isolated metabolites to mutant stains, has allowed the isolation of a large number of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbohydrate Chemistry and Synthesis
Share to Microbial Natural Products and Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24625190
DOI: 10.1021/ja501731p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biosynthesis of Mupirocin by <i>Pseudomonas fluorescens</i> NCIMB 10586 Involves Parallel PathwaysPMID 24625190Read ↗

Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.Semantic proximity Read ↗

In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism.Semantic proximity Read ↗

Phosphopantetheinylation and specificity of acyl carrier proteins in the mupirocin biosynthetic cluster.Semantic proximity Read ↗

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.Semantic proximity Read ↗

Metabolic reshaping drives novel melanin production from tryptophan in a cystic fibrosis <i>Pseudomonas aeruginosa</i> clinical isolateSemantic proximity Read ↗

Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens.Semantic proximity Read ↗

Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic MupirocinSemantic proximity Read ↗

Defense Responses of <i>Fusarium oxysporum</i> to 2,4-Diacetylphloroglucinol, a Broad-Spectrum Antibiotic Produced by <i>Pseudomonas fluorescens</i>Semantic proximity Read ↗

A genomic and transcriptomic approach to investigate the blue pigment phenotype in Pseudomonas fluorescens.Semantic proximity Read ↗

Analysis of rILERS, an isoleucyl-tRNA synthetase gene associated with mupirocin production by Pseudomonas fluorescens NCIMB 10586.Semantic proximity Read ↗

Biosynthesis of the pyoverdine siderophore of Pseudomonas aeruginosa involves precursors with a myristic or a myristoleic acid chain.Semantic proximity Read ↗

Production of novel fusarielins by ectopic activation of the polyketide synthase 9 cluster in Fusarium graminearum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.