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Article

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.

Angewandte Chemie (International ed. in English) - 27 Mar 2017

Gao Shu-Shan, Wang Luoyi, Song Zhongshu, Hothersall Joanne, Stevens Elton R, Connolly Jack, Winn Peter J, Cox Russell J, Crump Matthew P, Race Paul R, Thomas Christopher M, Simpson Thomas J, Willis Christine L

Abstract excerpt

Thiomarinol and mupirocin are assembled on similar polyketide/fatty acid backbones and exhibit potent antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA). They both contain a tetrasubstituted tetrahydropyran (THP) ring that is essential for biological activity. Mupirocin is a mixture of pseudomonic acids (PAs). Isolation of the novel compound mupirocin P, which contains a...

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PMID: 28181382
DOI: 10.1002/anie.201611590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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