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Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.

Chemistry & biology - 1 Jul 2005

Cooper Sian M, Laosripaiboon Wanpen, Rahman Ayesha S, Hothersall Joanne, El-Sayed A Kassem, Winfield Christopher, Crosby John, Cox Russell J, Simpson Thomas J, Thomas Christopher M

Abstract excerpt

Mupirocin, a polyketide-derived antibiotic from Pseudomonas fluorescens NCIMB10586, is a mixture of pseudomonic acids (PA) that target isoleucyl-tRNA synthase. The mup gene cluster encodes both type I polyketide synthases and monofunctional enzymes that should play a role during the conversion of the product of the polyketide synthase into the active antibiotic (tailoring). By in-frame deletion analysis of...

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PMID: 16039529
DOI: 10.1016/j.chembiol.2005.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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