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In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism.

Chembiochem : a European journal of chemical biology - 16 Jun 2008

Wu Ji'en, Hothersall Joanne, Mazzetti Carlo, O'Connell Yvonne, Shields Jennifer A, Rahman Ayesha S, Cox Russell J, Crosby John, Simpson Thomas J, Thomas Christopher M, Willis Christine L

Abstract excerpt

A common feature of the mupirocin and other gene clusters of the AT-less polyketide synthase (PKS) family of metabolites is the introduction of carbon branches by a gene cassette that contains a beta-hydroxy-beta-methylglutaryl CoA synthase (HMC) homologue and acyl carrier protein (ACP), ketosynthase (KS) and two crotonase superfamily homologues. In vivo studies of Pseudomonas fluorescens strains in which any of...

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PMID: 18465759
DOI: 10.1002/cbic.200800085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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