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Article

Phosphopantetheinylation and specificity of acyl carrier proteins in the mupirocin biosynthetic cluster.

Chembiochem : a European journal of chemical biology - 25 Jan 2010

Shields Jennifer A, Rahman Ayesha S, Arthur Christopher J, Crosby John, Hothersall Joanne, Simpson Thomas J, Thomas Christopher M

Abstract excerpt

Acyl carrier proteins are vital for the biosynthesis of fatty acids and polyketides. The mupirocin biosynthetic cluster of Pseudomonas fluorescens encodes eleven type I ACPs embedded in its multifunctional polyketide synthase (PKS) proteins plus five predicted type II ACPs (mAcpA-E) that are known to be essential for mupirocin biosynthesis by deletion and complementation analysis. MupN is a putative Sfp-type...

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PMID: 20013982
DOI: 10.1002/cbic.200900565

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