Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer.

Oncotarget - 18 Jul 2017

Taniguchi Hiroaki, Hoshino Daisuke, Moriya Chiharu, Zembutsu Hitoshi, Nishiyama Nobuhiro, Yamamoto Hiroyuki, Kataoka Kazunori, Imai Kohzoh

Abstract excerpt

PR domain zinc finger protein 14 (PRDM14) maintains stemness in embryonic stem cells via epigenetic mechanisms. Although PRDM14 is elevated in several cancers, it is unclear if and how PRDM14 confers stem cell-like properties and epigenetic changes to cancer cells. Here, we examined the phenotypic characteristics and epigenetic and gene expression profiles of cancer cells that differentially express PRDM14, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Silencing
Share to Lymphocytes, Tumor-Infiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Metastasis

Share to Neoplastic Stem Cells

Share to Organ Specificity

Share to Proto-Oncogene Mas

Share to RNA-Binding Proteins

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 28423353
DOI: 10.18632/oncotarget.16776
PMCID: PMC5564528

Genes

PRDM14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer.PMID 28423353Read ↗

Cell type-specific DNA methylation patterns in the human breast.Semantic proximity Read ↗

PRDM1 promotes the stemness of gastric cancer cells by enhancing the transactivation of MycSemantic proximity Read ↗

E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer.Semantic proximity Read ↗

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.Semantic proximity Read ↗

HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cellsSemantic proximity Read ↗

Pathways of Proliferation and Antiapoptosis Driven in Breast Cancer Stem Cells by Stem Cell Protein Piwil2Semantic proximity Read ↗

Zinc finger and SCAN domain containing 1, ZSCAN1, is a novel stemness-related tumor suppressor and transcriptional repressor in breast cancer targeting TAZSemantic proximity Read ↗

A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancerSemantic proximity Read ↗

Epigenetic patterns of embryonic and adult stem cellsSemantic proximity Read ↗

PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expressionSemantic proximity Read ↗

PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone ModificationsSemantic proximity Read ↗

ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.