Article
Structure-function relationship of a plant NCS1 member--homology modeling and mutagenesis identified residues critical for substrate specificity of PLUTO, a nucleobase transporter from Arabidopsis.
PloS one - 1 Jan 2014
Witz Sandra, Panwar Pankaj, Schober Markus, Deppe Johannes, Pasha Farhan Ahmad, Lemieux M Joanne, Möhlmann Torsten
Abstract excerpt
Plastidic uracil salvage is essential for plant growth and development. So far, PLUTO, the plastidic nucleobase transporter from Arabidopsis thaliana is the only known uracil importer at the inner plastidic membrane which represents the permeability barrier of this organelle. We present the first homology model of PLUTO, the sole plant NCS1 member from Arabidopsis based on the crystal structure of the benzyl...
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