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Article

Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP.

PloS one - 1 Jan 2014

Monecke Thomas, Buschmann Juliane, Neumann Piotr, Wahle Elmar, Ficner Ralf

Abstract excerpt

5'-nucleotidases catalyze the hydrolytic dephosphorylation of nucleoside monophosphates. As catabolic enzymes they contribute significantly to the regulation of cellular nucleotide levels; misregulation of nucleotide metabolism and nucleotidase deficiencies are associated with a number of diseases. The seven human 5'-nucleotidases differ with respect to substrate specificity and cellular localization. Recently,...

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Identifiers

PMID: 24603684
DOI: 10.1371/journal.pone.0090915
PMCID: PMC3946280

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