Article
Copy number variation in the CCL4L gene is associated with susceptibility to acute rejection in lung transplantation.
Genes and immunity - 1 Apr 2009
Colobran R, Casamitjana N, Roman A, Faner R, Pedrosa E, Arostegui J I, Pujol-Borrell R, Juan M, Palou E
Abstract excerpt
Lung transplantation (LT) has become an accepted therapy for selected patients with advanced lung disease. One of the main limitations to successful LT is rejection of the transplanted organ where chemokines are pivotal mediators. Here, we test the relationship between copy number variation (CNV) in the CCL4L chemokine gene and rejection risk in LT patients (n=161). Patients with no acute rejection showed a...
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