Lack of validation of genetic variants associated with anti-tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis.

doi:10.1186/ar4504

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Article

Lack of validation of genetic variants associated with anti-tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis.

Arthritis research & therapy - 11 Mar 2014

Márquez Ana, Ferreiro-Iglesias Aida, Dávila-Fajardo Cristina L, Montes Ariana, Pascual-Salcedo Dora, Perez-Pampin Eva, Moreno-Ramos Manuel J, García-Portales Rosa, Navarro Federico, Moreira Virginia, Magro César, Caliz Rafael, Ferrer Miguel Angel, Alegre-Sancho Juan José, Joven Beatriz, Carreira Patricia, Balsa Alejandro, Vasilopoulos Yiannis, Sarafidou Theologia, Cabeza-Barrera José, Narvaez Javier, Raya Enrique, Cañete Juan D, Fernández-Nebro Antonio, Ordóñez María del Carmen, de la Serna Arturo R, Magallares Berta, Gomez-Reino Juan J, González Antonio, Martín Javier

Abstract excerpt

INTRODUCTION: In this study, our aim was to elucidate the role of four polymorphisms identified in a prior large genome-wide association study (GWAS) in which the investigators analyzed the responses of patients with rheumatoid arthritis (RA) to treatment with tumor necrosis factor inhibitors (TNFi). The authors of that study reported that the four genetic variants were significantly associated. However, none of...

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PMID: 24612463
DOI: 10.1186/ar4504
PMCID: PMC4060376

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