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Article

Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.

PloS one - 1 Jan 2013

Zervou Maria I, Myrthianou Efsevia, Flouri Irene, Plant Darren, Chlouverakis Gregory, Castro-Giner Francesc, Rapsomaniki Panayiota, Barton Anne, Boumpas Dimitrios T, Sidiropoulos Prodromos, Goulielmos George N

Abstract excerpt

Treatment strategies blocking tumor necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA), showing beneficial effects in approximately 50-60% of the patients. However, a significant subset of patients does not respond to anti-TNF agents, for reasons that are still unknown. The aim of this study was to validate five single nucleotide polymorphisms (SNPs) of PTPRC, CD226,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24040234
DOI: 10.1371/journal.pone.0074375
PMCID: PMC3769251

Genes

TNF
AFF3
CHUK
PTPRC
STAT4
TRAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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