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Article

Structural basis for ovarian tumor domain-containing protein 1 (OTU1) binding to p97/valosin-containing protein (VCP).

The Journal of biological chemistry - 2 May 2014

Kim Su Jin, Cho Jinhong, Song Eun Joo, Kim Soo Jin, Kim Ho Min, Lee Kyung Eun, Suh Se Won, Kim Eunice EunKyeong

Abstract excerpt

Valosin-containing protein (VCP), also known as p97, is an AAA(+) ATPase that plays an essential role in a broad array of cellular processes including the endoplasmic reticulum-associated degradation (ERAD) pathway. Recently, ERAD-specific deubiquitinating enzymes have been reported to be physically associated with VCP, although the exact mechanism is not yet clear. Among these enzymes is ovarian tumor...

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Source

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Identifiers

PMID: 24610782
DOI: 10.1074/jbc.M113.523936
PMCID: PMC4007425

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Structural basis for ovarian tumor domain-containing protein 1 (OTU1) binding to p97/valosin-containing protein (VCP).PMID 24610782Read ↗

Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in CancerSemantic proximity Read ↗

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesisSemantic proximity Read ↗

Valosin-Containing Protein (VCP)/p97 Oligomerization.Semantic proximity Read ↗

Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitorsSemantic proximity Read ↗

ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif.Semantic proximity Read ↗

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system.Semantic proximity Read ↗

The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.Semantic proximity Read ↗

p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation.Semantic proximity Read ↗

D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP.Semantic proximity Read ↗

Targeting p97 to Disrupt Protein Homeostasis in CancerSemantic proximity Read ↗

Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma.Semantic proximity Read ↗

Control of p97 function by cofactor binding.Semantic proximity Read ↗

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