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Article

Control of p97 function by cofactor binding.

FEBS letters - 14 Sept 2015

Buchberger Alexander, Schindelin Hermann, Hänzelmann Petra

Abstract excerpt

p97 (also known as Cdc48, Ter94, and VCP) is an essential, abundant and highly conserved ATPase driving the turnover of ubiquitylated proteins in eukaryotes. Even though p97 is involved in highly diverse cellular pathways and processes, it exhibits hardly any substrate specificity on its own. Instead, it relies on a large number of regulatory cofactors controlling substrate specificity and turnover. The...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Binding

Share to Protein Structure, Tertiary

Share to Sequence Homology, Amino Acid

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Source

Identifiers

PMID: 26320413
DOI: 10.1016/j.febslet.2015.08.028

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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