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Article

Targeting p97 to Disrupt Protein Homeostasis in Cancer

3 Aug 2016

Abstract excerpt

Cancer cells are addicted to numerous non-oncogenic traits that enable them to thrive. Proteotoxic stress is one such non-oncogenic trait that is experienced by all tumor cells owing to increased genomic abnormalities and the resulting synthesis and accumulation of non-stoichiometric amounts of cellular proteins. This imbalance in the amounts of proteins ultimately culminates in proteotoxic stress. p97, or...

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PMID: 27536557
DOI: 10.3389/fonc.2016.00181

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