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Article

Cannabinoid receptor signaling regulates liver development and metabolism.

Development (Cambridge, England) - 15 Feb 2016

Liu Leah Y, Alexa Kristen, Cortes Mauricio, Schatzman-Bone Stephanie, Kim Andrew J, Mukhopadhyay Bani, Cinar Resat, Kunos George, North Trista E, Goessling Wolfram

Abstract excerpt

Endocannabinoid (EC) signaling mediates psychotropic effects and regulates appetite. By contrast, potential roles in organ development and embryonic energy consumption remain unknown. Here, we demonstrate that genetic or chemical inhibition of cannabinoid receptor (Cnr) activity disrupts liver development and metabolic function in zebrafish (Danio rerio), impacting hepatic differentiation, but not endodermal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26884397
DOI: 10.1242/dev.121731
PMCID: PMC4760316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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