Article

The CB <sub>1</sub> receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls

2023-07-28

Abstract excerpt

Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene cause a form of autosomal recessive non-syndromic intellectual disability (ARNSID) that is modelled by knocking-out the mouse Crbn gene. A reduction in excitatory neurotransmission has been proposed as an underlying mechanism of the disease, but the intimate fac...

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Literature Corpus work: abe7b69f-ee5b-5760-ab77-80b1fd7b9519
DOI: 10.1101/2023.07.24.550332

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