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Article

The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls.

EMBO molecular medicine - 1 Apr 2024

Costas-Insua Carlos, Hermoso-López Alba, Moreno Estefanía, Montero-Fernández Carlos, Álvaro-Blázquez Alicia, Maroto Irene B, Sánchez-Ruiz Andrea, Diez-Alarcia Rebeca, Blázquez Cristina, Morales Paula, Canela Enric I, Casadó Vicent, Urigüen Leyre, Perea Gertrudis, Bellocchio Luigi, Rodríguez-Crespo Ignacio, Guzmán Manuel

Abstract excerpt

Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene cause a form of autosomal recessive non-syndromic intellectual disability (ARNSID) that is modelled by knocking-out the mouse Crbn gene. A reduction in excitatory neurotransmission has been proposed as an underlying mechanism of the disease. However, the precise...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Cannabinoid, CB1

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Source

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Identifiers

PMID: 38514794
DOI: 10.1038/s44321-024-00054-w
PMCID: PMC11018632

Genes

CRBN
DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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