Article

mTOR driven gene transcription is required for cholesterol production in neurons of the developing cerebral cortex

2020-09-04

Abstract excerpt

Dysregulated mammalian target of rapamycin (mTOR) activity is associated with various neurodevelopmental disorders ranging from idiopathic autism spectrum disorders to syndromes caused by single gene defects. This suggests that maintaining mTOR activity levels in a physiological range is essential for brain development and functioning. Upon activation, mTOR regulates a variety of cellular processes such as cell gr...

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Literature Corpus work: 678d40c7-a95f-5121-ac06-e6ce38025275
DOI: 10.1101/2020.09.04.282772

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