Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity

1 Jan 2014

Abstract excerpt

The regulation of cell growth and division occurs in an accurate sequential manner. It is dictated by the accumulation of cyclins (CCNs) and cyclin-dependent kinases (CDKs) complexes and degradation of CCNs. In human tumors, instead, the cell cycle is deregulated, causing absence of differentiation and aberrant cell growth. Oncogenic alterations of CCNs, CDKs, and CDKIs have been reported in more than 90% of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24605326
DOI: 10.1155/2014/361020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic PredictivityPMID 24605326Read ↗

Investigational drugs targeting cyclin-dependent kinases for the treatment of cancer: an update on recent findings (2013-2016)Semantic proximity Read ↗

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer.Semantic proximity Read ↗

Cell cycle regulation and anticancer drug discoverySemantic proximity Read ↗

A review on the role of cyclin dependent kinases in cancersSemantic proximity Read ↗

Cyclin-dependent protein kinases and cell cycle regulation in biology and diseaseSemantic proximity Read ↗

Inhibitors of Cell Cycle Kinases: Recent Advances and Future Prospects as Cancer TherapeuticsSemantic proximity Read ↗

Cell Cycle and CancerSemantic proximity Read ↗

Cell cycle checkpoint revolution: targeted therapies in the fight against malignant tumorsSemantic proximity Read ↗

Cell cycle control as a basis for cancer drug development (Review).Semantic proximity Read ↗

Cancer Therapy: Targeting Cell Cycle RegulatorsSemantic proximity Read ↗

CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilitiesSemantic proximity Read ↗

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.