Article
Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations.
Science (New York, N.Y.) - 31 May 1991
Wilson D K, Rudolph F B, Quiocho F A
Abstract excerpt
The crystal structure of a murine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine ribonucleoside, a nearly ideal transition-state analog, has been determined and refined at 2.4 angstrom resolution. The structure is folded as an eight-stranded parallel alpha/beta barrel with a deep pocket at the beta-barrel COOH-terminal end wherein the inhibitor and a zinc are bound and completely sequestered. The...
Topics
- Adenosine Deaminase
- Amino Acid Sequence
- Animals
- Binding Sites
- Catalysis
- Crystallization
- Immunologic Deficiency Syndromes
- Mice
- Models, Molecular
- Molecular Structure
- Mutation