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Article

Crystallographic analysis of the reaction cycle of 2',3'-cyclic nucleotide 3'-phosphodiesterase, a unique member of the 2H phosphoesterase family.

Journal of molecular biology - 15 Nov 2013

Myllykoski Matti, Raasakka Arne, Lehtimäki Mari, Han Huijong, Kursula Inari, Kursula Petri

Abstract excerpt

2H phosphoesterases catalyze reactions on nucleotide substrates and contain two conserved histidine residues in the active site. Very limited information is currently available on the details of the active site and substrate/product binding during the catalytic cycle of these enzymes. We performed a comprehensive X-ray crystallographic study of mouse 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), a...

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Identifiers

PMID: 23831225
DOI: 10.1016/j.jmb.2013.06.012
PMCID: PMC7094350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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