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Article

Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese.

Cancer chemotherapy and pharmacology - 1 Jun 2017

Tanabe Yuko, Shimizu Chikako, Hamada Akinobu, Hashimoto Kenji, Ikeda Kazutaka, Nishizawa Daisuke, Hasegawa Junko, Shimomura Akihiko, Ozaki Yukinori, Tamura Nobuko, Yamamoto Harukaze, Yunokawa Mayu, Yonemori Kan, Takano Toshimi, Kawabata Hidetaka, Tamura Kenji, Fujiwara Yasuhiro

Abstract excerpt

PURPOSE: Whether age and inter-individual variability of pharmacogenetics are risk factors for paclitaxel-induced peripheral neuropathy (PIPN) is inconclusive. This study was conducted to evaluate the influence of previously investigated single nucleotide polymorphisms (SNPs) and age, using genotype data from a prospective study of paclitaxel-related toxicity in Japanese patients with breast cancer. METHODS:...

Read the complete abstract on PubMed

Topics

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Share to Antineoplastic Agents, Phytogenic
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C8

Share to Organic Anion Transporters, Sodium-Independent

Share to Paclitaxel

Share to Peripheral Nervous System Diseases

Share to Sensory Receptor Cells

Share to Solute Carrier Organic Anion Transporter Family Member 1B3

Source

Identifiers

PMID: 28447211
DOI: 10.1007/s00280-017-3314-9

Genes

ABCB1

Variants

rs4149117
rs4149117
rs4149117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese.PMID 28447211Read ↗

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