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Article

Transgenic Mice for Real-Time Visualization of cGMP in Intact Adult Cardiomyocytes

6 Mar 2014

Abstract excerpt

RATIONALE: 3',5'-Cyclic guanosine monophosphate (cGMP) is an important second messenger that regulates cardiac contractility and protects the heart from hypertrophy. However, because of the lack of real-time imaging techniques, specific subcellular mechanisms and spatiotemporal dynamics of cGMP in adult cardiomyocytes are not well understood. OBJECTIVE: Our aim was to generate and characterize a novel cGMP sensor...

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Cardiac electrophysiology and arrhythmias
Nitric Oxide and Endothelin Effects
Phosphodiesterase function and regulation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24599804
DOI: 10.1161/circresaha.114.302437

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