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Article

Early calcium and cardiac contraction defects in a model of phospholamban R9C mutation in zebrafish.

Journal of molecular and cellular cardiology - 1 Dec 2022

Vicente Manuel, Salgado-Almario Jussep, Valiente-Gabioud Ariel A, Collins Michelle M, Vincent Pierre, Domingo Beatriz, Llopis Juan

Abstract excerpt

The phospholamban mutation Arg 9 to Cys (R9C) has been found to cause a dilated cardiomyopathy in humans and in transgenic mice, with ventricular dilation and premature death. Emerging evidence suggests that phospholamban R9C is a loss-of-function mutation with dominant negative effect on SERCA2a activity. We imaged calcium and cardiac contraction simultaneously in 3 and 9 days-post-fertilization (dpf) zebrafish...

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Identifiers

PMID: 36273660
DOI: 10.1016/j.yjmcc.2022.10.005

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