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Article

LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk.

British journal of cancer - 15 Apr 2014

Tajuddin S M, Amaral A F S, Fernández A F, Chanock S, Silverman D T, Tardón A, Carrato A, García-Closas M, Jackson B P, Toraño E G, Márquez M, Urdinguio R G, García-Closas R, Rothman N, Kogevinas M, Real F X, Fraga M F, Malats N

Abstract excerpt

BACKGROUND: Aberrant global DNA methylation is shown to increase cancer risk. LINE-1 has been proven a measure of global DNA methylation. The objectives of this study were to assess the association between LINE-1 methylation level and bladder cancer risk and to evaluate effect modification by environmental and genetic factors. METHODS: Bisulphite-treated leukocyte DNA from 952 cases and 892 hospital controls was...

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Identifiers

PMID: 24595004
DOI: 10.1038/bjc.2014.67
PMCID: PMC3992509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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