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Prospective changes in global DNA methylation and cancer incidence and mortality

28 Jun 2016

Abstract excerpt

BACKGROUND: Methylation of repetitive elements Alu and LINE-1 in humans is considered a surrogate for global DNA methylation. Previous studies of blood-measured Alu/LINE-1 and cancer risk are inconsistent. METHODS: We studied 1259 prospective methylation measurements from blood drawn 1-4 times from 583 participants from 1999 to 2012. We used Cox regression to evaluate time-dependent methylation as a biomarker for...

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PMID: 27351216
DOI: 10.1038/bjc.2016.205

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