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Article

LINE1 methylation levels associated with increased bladder cancer risk in pre-diagnostic blood DNA among US (PLCO) and European (ATBC) cohort study participants.

Epigenetics - 1 Mar 2014

Andreotti Gabriella, Karami Sara, Pfeiffer Ruth M, Hurwitz Lauren, Liao Linda M, Weinstein Stephanie J, Albanes Demetrius, Virtamo Jarmo, Silverman Debra T, Rothman Nathaniel, Moore Lee E

Abstract excerpt

Global methylation in blood DNA has been associated with bladder cancer risk in case-control studies, but has not been examined prospectively. We examined the association between LINE1 total percent 5-methylcytosine and bladder cancer risk using pre-diagnostic blood DNA from the United States-based, Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial (PLCO) (299 cases/676 controls), and the...

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PMID: 24316677
DOI: 10.4161/epi.27386
PMCID: PMC4053459

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