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Article

Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study.

BMC medical genetics - 4 Mar 2014

Marson Fernando Augusto de Lima, Bertuzzo Carmen Silvia, Ribeiro Antonio Fernando, Ribeiro Jose Dirceu

Abstract excerpt

BACKGROUND: Cystic fibrosis (CF) clinically manifests with various levels of severity, which are thought to be modulated by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), modifier genes, and the environment. This study verified whether polymorphisms in modifier genes associated with glutathione (GSH) metabolism influence CF severity. METHODS: A cross-sectional study of 180 CF...

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Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glutathione S-Transferase pi

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Source

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Identifiers

PMID: 24593045
DOI: 10.1186/1471-2350-15-27
PMCID: PMC3973994

Genes

GCLC
GSTT1
CFTR
GSTM1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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