Article
Glutathione S-transferases related to P. aeruginosa lung infection in cystic fibrosis children: preliminary study.
Clinical biochemistry - 1 Jan 2009
Feuillet-Fieux Marie-Noëlle, Nguyen-Khoa Thao, Loriot Marie-Anne, Kelly Mairead, de Villartay Philippe, Sermet Isabelle, Verrier Patricia, Bonnefont Jean-Paul, Beaune Philippe, Lenoir Gérard, Lacour Bernard
Abstract excerpt
OBJECTIVES: In cystic fibrosis (CF) children, we investigated the predictive impact of glutathione S-transferases (GST) activity and genotypes P1, M1 and T1, and antioxidant levels on stage-severity of Pseudomonas aeruginosa lung infection. METHODS: GST activity was determined in whole blood by spectrophotometry, and GST genotypes by multiplex PCR RFLP for 36 CF and 9 control children. Levels of glutathione in...
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