Article
Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism.
Hepatology (Baltimore, Md.) - 1 Oct 2002
Henrion-Caude Alexandra, Flamant Cyril, Roussey Michel, Housset Chantal, Flahault Antoine, Fryer Anthony A, Chadelat Katarina, Strange Richard C, Clement Annick
Abstract excerpt
Liver disease in patients with cystic fibrosis (CF) is inconstant and has not yet been clearly related to any specific risk factor. While the expression of cystic fibrosis transmembrane conductance regulator (CFTR) is restricted to the biliary epithelium in the liver, recent findings indicate that CFTR modulates reduced glutathione (GSH) transport and that CFTR dysfunction creates an imbalance in the antioxidant...
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