Article
Genetic interaction of GSH metabolic pathway genes in cystic fibrosis.
BMC medical genetics - 10 Jun 2013
de Lima Marson Fernando Augusto, Bertuzzo Carmen Sílvia, Secolin Rodrigo, Ribeiro Antônio Fernando, Ribeiro José Dirceu
Abstract excerpt
BACKGROUND: Cystic fibrosis (CF) is a monogenic disease caused by CFTR gene mutations, with clinical expression similar to complex disease, influenced by genetic and environmental factors. Among the possible modifier genes, those associated to metabolic pathways of glutathione (GSH) have been considered as potential modulators of CF clinical severity. In this way it is of pivotal importance investigate gene...
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