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Article

DNA methylation changes in cystic fibrosis: Cause or consequence?

Clinical genetics - 1 Jul 2020

Scott Madeleine, De Sario Albertina

Abstract excerpt

Twin and sibling studies have shown that lung disease severity is variable among cystic fibrosis (CF) patients and affected to the same extent by genetic and nonheritable factors. Genetic factors have been thoroughly assessed, whereas the molecular mechanisms whereby nonheritable factors contribute to the phenotypic variability of CF patients are still unknown. Epigenetic modifications may represent the missing...

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PMID: 32112395
DOI: 10.1111/cge.13731

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