Article
Cystic fibrosis modifier genes related to Pseudomonas aeruginosa infection.
Genes and immunity - 1 Jul 2011
Park J E, Yung R, Stefanowicz D, Shumansky K, Akhabir L, Durie P R, Corey M, Zielenski J, Dorfman R, Daley D, Sandford A J
Abstract excerpt
Cystic fibrosis (CF) is one of the most common life-shortening genetic disorders, and the CF transmembrane conductance regulator (CFTR) is the major causal gene. However, a substantial clinical variability among patients with identical CFTR genotypes suggests the presence of modifier genes. We tested the effect of four genes involved in Pseudomonas aeruginosa infection. Analysis of a primary cohort detected eight...
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