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DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis

14 Feb 2017

Abstract excerpt

Lung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the CFTR gene, polymorphic variations in disease modifier genes, and environmental exposure. The contribution of genetic factors has been extensively investigated, whereas the mechanism whereby environmental factors modulate the lung disease is unknown. In this project, we hypothesized that (i) reiterative...

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PMID: 28289476
DOI: 10.1186/s13148-016-0300-8

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