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Mastering organismal aging through the endoplasmic reticulum proteostasis network

31 Oct 2020

Abstract excerpt

The aging process is characterized by a progressive decline in the function of most tissues, representing the main risk factor in the development of a variety of human diseases. Studies in multiple animal models have demonstrated that interventions that improve the capacity to maintain endoplasmic reticulum (ER) proteostasis prolong life and healthspan. ER stress is monitored by the unfolded protein response...

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PMID: 33128506
DOI: 10.1111/acel.13265

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