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Antimicrobial Treatment Improves Mycobacterial Survival in Nonpermissive Growth Conditions

4 Mar 2014

Abstract excerpt

Antimicrobials targeting cell wall biosynthesis are generally considered inactive against nonreplicating bacteria. Paradoxically, we found that under nonpermissive growth conditions, exposure of Mycobacterium bovis BCG bacilli to such antimicrobials enhanced their survival. We identified a transcriptional regulator, RaaS (for regulator of antimicrobial-assisted survival), encoded by bcg1279 (rv1219c) as being...

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PMID: 24590482
DOI: 10.1128/aac.02774-13

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