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2′-5′-Oligoadenylate synthetase-like protein inhibits intracellular <i>M. tuberculosis</i> replication and promotes proinflammatory cytokine secretion

2019-10-28

Abstract excerpt

Host cytoplasmic surveillance pathways are known to elicit type I interferon (IFN) responses which are crucial to antimicrobial defense mechanisms. Oligoadenylate synthetase-like (OASL) protein has been extensively characterized as a part of the anti-viral mechanism, however a number of transcriptomic studies reveal its upregulation in response to infection with a wide variety of intracellular bacterial pathogens....

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Literature Corpus work
a75d17fc-afe3-54da-84c4-6cc659880b4f
DOI
10.1101/821173
Open publication

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2′-5′-Oligoadenylate synthetase-like protein inhibits intracellular <i>M. tuberculosis</i> replication and promotes proinflammatory cytokine secretionDOI 10.1101/821173
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