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Article

SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome

3 Mar 2014

Abstract excerpt

Aberrant expression of the secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) gene, which encodes a matricellular protein that participates in normal tissue remodeling, is associated with a variety of diseases including cancer, but the contribution of SPARC to malignant growth remains controversial. We previously reported that SPARC was among the most upregulated genes in cytogenetically normal acute...

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PMID: 24590286
DOI: 10.1172/jci70921

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